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Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you may be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is essential that it have the right level of chromosome material; missing or extra material during conception or in an embryo or fetus can cause a female to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as Down syndrome.

Over 50% of all first trimester miscarriages are due to chromosome abnormalities. This number may be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The opportunity of experiencing a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage continue to possess a healthy pregnancy rather than miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this may be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in past times the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many different types of testing that can be done on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For that reason requirement, tissue that’s passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples neglect to grow and thus no results are available. Additionally, karyotyping struggles to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the correct result for the fetus or it could be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more prone to receive results and the outcomes are typically returned faster when microarray testing is used. Additionally, some laboratories are collecting an example of the mother’s blood simultaneously the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

I had a miscarriage If a chromosome abnormality is identified, the kind of abnormality found can be assessed to help answer fully the question: “Will this happen to me again?”. Usually, chromosome abnormalities in an embryo or fetus are not inherited and have a minimal possiblity to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your physician to do further studies to investigate the possibility of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss can help a couple of start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having a successful healthy pregnancy.